Turkish Journal of Physical Medicine and Rehabilitation 2013 , Vol 59 , Num 4

Effects of Aerobic Exercise on Bone-Specific Alkaline Phosphatase and Urinary CTX Levels in Premenopausal Wome

Alev Alp 1
1 Department of Physical Medicine and Rehabilitation, Uludağ University Faculty of Medicine, Bursa, Turkey DOI : 10.4274/tftr.93546

Objective: This study aimed to investigate the effects of moderate-intensity aerobic exercise on bone turnover by urinary cross-linked C-telopeptide of type I collagen (CTX) and serum bone-spesific alkaline phosphatase (BAP) in comparison with a control group.


Materials and Methods: 100 premenopausal volunteers from our outpatient unit were randomized into 2 equal groups. The exercise group (n=50) performed the exercise sessions supervised by a physiotherapist for 40 min a day, 5 times a week for a duration of 2 months. The control group (n=50) maintained their sedentary lifestyle for the duration. Urinary CTX and BAP levels in the subjects were measured before and at the end of the intervention.


Results: The changes in CTX and BAP from baseline were statistically significant in the exercise group for but not in the control group. When the groups were compared with each other, the exercise group was found to be superior to the control group for the change in CTX.


Conclusion: Two months of regular submaximal aerobic exercise decreased bone resorption rate in premenopausal sedentary women.

Keywords : Aerobic exercise, bone-spesific alkaline phosphatase, cross linked c telopeptide of type 1 collagen.