Turkish Journal of Physical Medicine and Rehabilitation 2021 , Vol 67 , Num 3

A rare localization of tuberculosis under infliximab treatment: Testicular involvement

Mehmet Nayımoğlu 1 ,Banu Sarıfakıoğlu 1 ,Kübra Ustaömer 1 ,Murat Akgül 2 ,Ayşegül Isal Arslan 3
1 Department of Physical Medicine and Rehabilitation, Namık Kemal University, School of Medicine, Tekirdağ, Turkey
2 Department of Urology, Namık Kemal University, School of Medicine, Tekirdağ, Turkey
3 Department of Pathology, Namık Kemal University, School of Medicine, Tekirdağ, Turkey
DOI : 10.5606/tftrd.2021.5135 Infliximab is an inhibitory of tumor necrosis factor-alpha which is used successfully for the treatment of inflammatory bowel disease and rheumatic disease. It has various side effects including injection-induced reactions, immunosuppression, demyelinating diseases, and cardiac effects. One of the most serious side effects is tuberculosis. In particular, the immunosuppressant drugs have a high risk of reactivating latent tuberculosis infection. Its activation probably may occur as an extra-pulmonary and, occasionally, may result in an unusual infection. Herein, we report a 30-year-old male case treated with infliximab and suffered from isolated testicular tuberculosis. Keywords : Infliximab, testicular tuberculosis, tumor necrosis factor-alpha