Ganglion is a cystic swelling arising from a joint capsule or from a tendon sheath. It has a synovial lining and contains a clear, thick, jelly-like fluid. Ganglia are often associated with underlying joint disorders, such as trauma, degeneration or inflammation. Specific attention is focused on those cystic masses appearing around the hip, knee, ankle and foot, shoulder, elbow, wrist and hand, spine, temporomandibular joints, and periosteum. In this paper we report a case of a ganglion cyst mimicking Morton neuroma and the appropriate literature is reviewed.